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関連する概念動画

Ion Channels01:19

Ion Channels

92.0K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
92.0K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.4K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.4K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.9K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.9K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

14.6K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
14.6K
Ionic Crystal Structures02:42

Ionic Crystal Structures

19.0K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
19.0K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.4K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.4K

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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

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形状固有の有機ケージに基づくヨウ素選択合成イオンチャネル

Bahiru Punja Benke1, Pulakesh Aich1, Younghoon Kim2

  • 1Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.

Journal of the American Chemical Society
|May 25, 2017
PubMed
まとめ

研究者はポルフィリンベースの有機ケージから 合成イオンチャネルを作成しました このケージは,脱水駆動メカニズムを通じてヨウ素イオンを選択的に輸送し,欠陥のあるチャネル置換のための生物学的ツールとしての可能性を示しています.

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Controllable Ion Channel Expression through Inducible Transient Transfection
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Controllable Ion Channel Expression through Inducible Transient Transfection

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Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
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Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins

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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

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Controllable Ion Channel Expression through Inducible Transient Transfection
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Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins
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科学分野:

  • 超分子化学
  • 材料科学
  • バイオ物理学

背景:

  • イオンチャネルは 生物学的プロセスに不可欠ですが 機能不全は病気を引き起こす可能性があります
  • 生物学的イオンチャネルに対する合成の代替品は,研究および治療用途に必要である.
  • ポルフィリンベースの共性有機ケージは 機能的な超分子材料を設計するための有望な支架を提供します

研究 の 目的:

  • 形状の持続性のあるポルフィリンベースの共性有機ケージを使用して合成イオンチャネルを開発する.
  • 合成チャネルのイオン選択性と輸送メカニズムを調査する.
  • 生体細胞におけるヨウ素輸送のための生物学的ツールとしての合成イオンチャネルの可能性を評価する.

主な方法:

  • ダイナミック・コヴァレンント・ケイシー (DCC) を用いたポルフィリン基の共性有機ケージの合成.
  • イオン輸送と選択性を研究するための水泡ベースの光測定法.
  • 平面性脂質二層ベースの単一チャネル記録は,チャネル活動を特徴づけます.
  • 生体細胞膜に横断するヨウ素輸送を評価する実験.

主要な成果:

  • 新しい合成イオンチャネルが,ポルフィリンベースの共性有機ケージから成功裏に合成されました.
  • 有機ケージは,他のアニオンに対するヨウ素イオンの選択的輸送を証明した.
  • ヨウ素輸送のための脱水駆動のチャネルメカニズムが確認されました.
  • 合成イオンチャネルはヨウ素の運搬を 活体細胞膜を通して促進した.

結論:

  • 開発されたポルフィリンベースの共性有機ケージは,効果的な合成イオンチャネルとして機能します.
  • 合成チャネルは脱水メカニズムによって誘導されるヨウ素イオンに対する高い選択性を示す.
  • この合成イオンチャネルは 生命体内の欠陥イオイドチャネルを修復する 生物学的ツールとして 潜在力を備えています