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Updated: Mar 1, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Published on: June 8, 2022

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Gタンパク質との複合体における活性化されたGLP-1受容体の冷凍-EM構造

Yan Zhang1, Bingfa Sun2, Dan Feng2

  • 1Life Sciences Institute and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Nature
|May 25, 2017
PubMed
まとめ

グルカゴン型ペプチド1 (GLP-1) は,細胞外ループと膜内核によって形成されたポケットに結合することによって,その受容体 (GLP-1R) を活性化します. この構造的洞察は,GLP-1R-Gs複合体の形成を明らかにし,B級GPCR活性化の理解を進める.

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