FSHを阻害すると,熱生成脂肪組織が形成され,体脂肪が減少する
Peng Liu1, Yaoting Ji1,2, Tony Yuen1
1Department of Medicine, and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Nature
|May 25, 2017
まとめ
卵泡刺激ホルモン (FSH) を標的とする新しい抗体は,脂肪組織を減少させ,マウスの骨質を増加させます. この発見は 肥満と骨粗鬆症の両方に対する 治療の可能性を秘めています
科学分野:
- 内分泌学
- 代謝に関する研究
- 骨の生物学
背景:
- 閉経は骨の減量と内臓脂肪の増加に関連しています.
- 卵泡刺激ホルモンは,これらの閉経後の変化に役割を果たします.
研究 の 目的:
- ポリクローン抗体でFSHβサブユニットを標的にする効果を調査する.
- 肥満と骨粗鬆症の治療戦略を探求する
主な方法:
- FSH βサブユニットを標的としたポリクローナル抗体を野生型のマウスに投与する.
- 脂肪組織,骨質,および茶色脂肪組織活性化の分析.
- FSH受容体 (Fshr) の遺伝的ハプロイン不全との比較
主要な成果:
- FSHβサブユニット抗体はマウスの脂肪組織を著しく減少させた.
- 抗体治療は,Fshr遺伝子ハプロイン不全の効果を模倣した.
- 脂肪組織の茶色化,ミトコンドリア密度の増加,熱生成の活性化が観察されました.
- 骨の質量も前述の通り増加した.
結論:
- 特定の抗体でFSHβサブユニットを標的にすると,脂肪の蓄積が減り,骨質が増加します.
- このアプローチは 肥満と骨粗鬆症の同時治療に 有望です
- FSHの作用を阻害することは,代謝と骨の健康のための新しい治療法です.
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