皮膚の調節性T細胞は,上皮幹細胞の分化を促進する

Niwa Ali¹, Bahar Zirak², Robert Sanchez Rodriguez²

¹Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Cutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.

Cell

|May 30, 2017

まとめ

皮膚の調節性T細胞 (Tregs) は,幹細胞の増殖と分化を促進することによって,毛皮の再生を促進します. 皮膚Tregは,毛皮幹細胞の機能と再生をサポートするために,ジャガード1を使用します.

科学分野:

免疫学
皮膚科
幹細胞生物学

背景:

組織ホメオスタシスは免疫細胞と幹細胞に依存しています
免疫細胞と幹細胞の相互作用は,特に皮膚ではよく理解されていません.
調節性T細胞 (Tregs) は,毛の幹細胞 (HFSCs) を含む毛 (HFs) の近くにある.

研究の目的:

ヘアフォリクル (HF) とヘアフォリクル幹細胞 (HFSC) の生物学におけるTregsの役割を調査する.
TregsがHF再生に影響を与えるメカニズムを解明する.

主な方法:

Treg機能の評価のための系統特有の細胞減少.
トレグとHFSCの転写性およびフェノタイプのプロファイリング
皮膚に居住するTregsにおけるJagged 1 (Jag1) 発現の分析

主要な成果:

Tregsは,HFSCの増殖と分化を促進します.
皮膚に宿るTregsはジャガード1の高いレベルを表現する.
TregsのJag1発現は,HFSC機能と効率的なHF再生に不可欠です.

結論:

Tregsは皮膚毛胞の生物学において重要な役割を果たします.
TregsはHFSCの機能を促進し,それによって毛皮の再生を促進します.
ジャガド1は,毛皮再生におけるTreg機能の重要な媒介体である.

キーワード:

ジャガード 1 ノッチアロペシア・エリアタ髪の毛髪の毛の幹細胞髪の再生規制T細胞皮膚について

さらに関連する動画

08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

29.1K

15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

16.5K

関連する概念動画

01:12

Renewal of Skin Epidermal Stem Cells

3.1K

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...

3.1K

01:24

T Cell Types and Functions

2.9K

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

2.9K

01:19

Clinical Applications of Epidermal Stem Cells

3.4K

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

3.4K

01:26

Stem Cell Niche

6.5K

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

6.5K

01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.5K

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

2.5K

01:01

Regulation of Hematopoietic Stem Cells

4.2K

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...