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Updated: Mar 1, 2026

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
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インターフェロン-γは,抗腫瘍免疫を促進する Treg 脆弱性を促進する

Abigail E Overacre-Delgoffe1, Maria Chikina2, Rebekah E Dadey3

  • 1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cell
|May 30, 2017
PubMed
まとめ

制御性T細胞 (Tregs) は抗腫瘍免疫を阻害する. ニューロピリン-1欠乏症のTregsからのインターフェロン・ガンマによって引き起こされる彼らの脆弱性は,腫瘍のクリアランスと免疫療法の応答を高めます.

キーワード:
PD-1 についてガンに対する免疫療法インターフェロン-γインターフェロン-γ受容体ニューロピリン-1規制T細胞腫瘍免疫学腫瘍の微小環境

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