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心血管機能と脳の磁気共鳴画像 認知症は心血管駆動疾患ですか?
Albert de Roos1, Jeroen van der Grond2, Gary Mitchell2
1From Leiden University Medical Center, Department of Radiology, The Netherlands (A.d.R., J.v.d.G., J.W.); and Cardiovascular Engineering, Inc, Norwood, MA (G.M.). a.de_roos@lumc.nl.
Circulation
|June 1, 2017
まとめ
老化や高血圧に伴う大動脈硬化が 脳への血流を阻害し 認知機能低下や認知症を引き起こす可能性があります MRIによる早期発見は 心血管と脳のつながりの予防策となるかもしれません
科学分野:
- 心血管医学
- 神経学
- 医療用イメージング
背景:
- 側近大動脈は 脳の血流と脈動を調節します
- 老化と高血圧に関連した 大動脈の硬化は 脳と心臓の健康に悪影響を及ぼします
- これは脳小血管疾患,心不全,認知機能低下,血管性認知症につながる可能性があります.
研究 の 目的:
- 大動脈の硬化と 認知の低下の間の 病理学的関係を調べる
- 認知症における 心血管疾患の役割を強調するためです
- 予防と治療のための潜在的な標的を特定する.
主な方法:
- 磁気共鳴画像 (MRI) を使って近親大動脈と左心室の機能を評価する.
- 大動脈の波の速度と伸縮性を測定する
- MRIを用いて脳小血管疾患 (微小出血,白質高強度) の初期および後期の兆候を評価する.
- 白質の臨床前変化と 脳の微小血管の脈動性について 研究しています
主要な成果:
- 大動脈の硬直は 脳損傷や心不全の 重要な危険因子です
- 脳小血管疾患と心不全は 認知機能低下と血管性認知症と関連しています
- MRIは認知障害に関連した 動脈と脳の機能的および構造的な変化を検出できます
結論:
- 心血管疾患 特に大動脈硬化が 認知機能低下や認知症の 主な原因です
- 早期発見と心臓血管-脳軸への介入は 極めて重要です
- 先進的なMRI技術は 臨床前の変化を診断し 予防戦略を導き出すのに 有望です
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