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Updated: Mar 1, 2026

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

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単細胞タンパク質状態の遺伝子配線マップは,GPCR信号のオフスイッチを明らかにする

Markus Brockmann1, Vincent A Blomen1, Joppe Nieuwenhuis1

  • 1Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.

Nature
|June 1, 2017
PubMed
まとめ

研究者はヒトの細胞内の タンパク質の活性に対する 遺伝的制御をマッピングしました 彼らは,AKT経路の重要な調節体としてKCTD5を特定し,それがGPCR信号のオフスイッチとして作用することを発見しました.

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