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年齢に関連する自律性アルドステロン症

Kazutaka Nanba1, Anand Vaidya1, Gordon H Williams1

  • 1From Departments of Molecular and Integrative Physiology & Internal Medicine, University of Michigan, Ann Arbor (K.N., I.Z., W.E.R.); Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (A.V., G.H.W.); and Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor (T.E., W.E.R.).

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|June 2, 2017
PubMed
まとめ

老化によりアルドステロンの生成が影響され 心血管疾患のリスクが増加します 高齢者は正常なCYP11B2発現が低下したが,アルドステロン産生細胞群が増加し,自律的なアルドステロニズムを示唆している.

キーワード:
年老化アルドステロンアルドステロン産生細胞群サイトクロームP-450 CYP11B2主要アルドステロン症レニン

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科学分野:

  • 内分泌学
  • 心血管疾患の研究
  • 老化 の 生物学

背景:

  • 老化と不適切なアルドステロン分泌は心臓血管疾患のリスク要因です.
  • アルドステロン分泌と生理学に対する老化の具体的な影響は不明である.

研究 の 目的:

  • 腎上腺における老化とアルドステロン合成酵素 (CYP11B2) 発現の関係を調査する.
  • 人における年齢とレニン・アニオテンシン・アルドステロン系 (RAAS) の生理学的関連性を評価する.

主な方法:

  • 127人の腎上腺 (9ヶ月から68歳) のCYP11B2発現とアルドステロン産生細胞群を免疫ヒストキミアで調べた.
  • 多変量線形回帰を用いて,高ナトリウムと限られたナトリウムを摂取した677人の参加者 (年齢18~71歳) のRAAS生理学を分析した.

主要な成果:

  • アドレナルのCYP11B2発現は年齢とともに低下し,アルドステロン産生細胞群は増加した.
  • 高齢は高ナトリウムダイエットでアルドステロンとレニンの比率が高かった.
  • アルドステロンのナトリウム制限に対する反応は,高齢者において鈍化した.

結論:

  • 老化は,正常なCYP11B2発現の減少と,腎上腺におけるアルドステロン産生細胞群の増加と関連しています.
  • このパターンは,年齢に関連した自律的なアルドステロン化とアルドステロン生理学的変化を示唆しています.
  • これらの発見は,高齢者の心血管疾患のリスクの増加を説明する可能性がある.