関連する実験動画

Updated: Mar 1, 2026

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
06:58

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling

Published on: October 7, 2021

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哺乳類のリボインタラクトームは,リボソームの機能的多様性と異質性を明らかにする

Deniz Simsek1, Gerald C Tiu1, Ryan A Flynn2

  • 1Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.

Cell
|June 3, 2017
PubMed
まとめ

研究者らは,哺乳類のリボソームと相互作用する何百ものリボソーム関連タンパク質 (RAP) を発見し,細胞代謝とタンパク質発現における新しい調節作用を明らかにした. この研究は,リボソームにおける重要な翻訳後の修正としてウフミレーションを特定しています.

キーワード:
PKM についてRNA結合タンパク質エンドプラズマの網膜メタボリズムリボソームリボソームの異質性翻訳ウフミレーション

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Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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The technique...
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Ribosome Structure and Assembly
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Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Ribosomal RNA Synthesis

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Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
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