哺乳類細胞の栄養素獲得戦略
Wilhelm Palm1, Craig B Thompson1
1Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Nature
|June 9, 2017
まとめ
細胞は代謝の柔軟性と生存のために様々な栄養素吸収経路を利用する. 成長因子や栄養センサーが この吸収を制御し 癌細胞の成長に不可欠です
科学分野:
- 細胞生物学
- 栄養素輸送の分子メカニズム
背景:
- 哺乳類の細胞は,トランスポーターや内解体経路を通じて,グルコース,アミノ酸,微量栄養素などの栄養素を輸入する.
- 代謝の柔軟性により 細胞は栄養素の供給に適応し 飢餓を生き延びることができます
- 静止状態の細胞はホメオスタシスを維持し,増殖する細胞は生体量生産のために栄養素の吸収を増加させることが必要で,しばしば成長因子によって刺激される.
研究 の 目的:
- 細胞の栄養素獲得戦略を 検討する
- 成長因子と細胞内センサーによる栄養素吸収の調節を研究する.
- ガン細胞の栄養吸収と成長における腫瘍抑制剤と腫瘍遺伝子の役割について議論する.
主な方法:
- 細胞の栄養素獲得に関する文献レビュー
- 成長因子と栄養センサを含む規制メカニズムの分析
- 腫瘍遺伝子と腫瘍抑制剤が細胞代謝に及ぼす影響の検討
主要な成果:
- 細胞は栄養素の輸入のために様々なトランスメブラントランスポーターとエンドリソーム経路を使用します.
- 成長因子は細胞の需要,特に増殖のために 栄養素の吸収を動的に調節する.
- 細胞内にある栄養センサーは 細胞のニーズに基づいて 栄養素の吸収を調整します
- 腫瘍遺伝子や腫瘍抑制剤によって引き起こされる 異常な栄養素の吸収は 癌細胞の生存と増殖をサポートします
結論:
- 細胞の栄養素獲得は,細胞の生存,恒常性および増殖に不可欠な厳格に規制されたプロセスです.
- これらの経路を理解することで 代謝の柔軟性と適応に関する洞察が得られます
- 栄養素吸収メカニズムをターゲットにすることで 癌治療の潜在的治療戦略を提示します
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