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関連する概念動画

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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Epistasis01:39

Epistasis

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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Signal Sequences and Sorting Receptors01:41

Signal Sequences and Sorting Receptors

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Signal sequences are short amino acid sequences that guide newly synthesized proteins to their proper location within the cell. Classical signal sequences are fifteen to sixty amino acids long and present at the N-terminus of a polypeptide chain. Each signal sequence has a conserved segment of basic residues towards their N terminus, a hydrophobic core, and a C-terminus rich in polar residues. The C-terminus also contains a signal cleavage site and features a -3 -1 sequence motif. The -3-1...
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What are Proteins?01:28

What are Proteins?

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Proteins are polymers of amino acids linked together by peptide bonds. Proteins and polypeptides are interchangeably used to refer to long chains of amino acids. However, polypeptides have a molecular weight of fewer than 10,000 daltons, while proteins have greater molecular weight.  Polypeptides with less than 20 amino acids are called oligopeptides or simply peptides. Interactions among the constituent amino acid side chains of proteins help them fold into a stable 3-dimensional...
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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配列にコードされた性質を持つポリメリックペプチド色素

Ayala Lampel1, Scott A McPhee1, Hang-Ah Park2

  • 1Advanced Science Research Center at the Graduate Center of the City University of New York, 85 Saint Nicholas Terrace, New York, NY 10031, USA.

Science (New York, N.Y.)
|June 10, 2017
PubMed
まとめ
この要約は機械生成です。

研究者はチロシンに富んだペプチドを用いて 調節可能なポリマー色素を開発しました ペプチド配列は 紫外線保護や色付けなどの pigmentの性質を制御し 化粧品や生物医学での応用を可能にします

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科学分野:

  • バイオマテリアル科学
  • ポリマー化学
  • バイオ物理学

背景:

  • メラニンは多用途のバイオポリマーで 紫外線保護,色付け,抗酸化機能を提供します.
  • メラニンの性質は,その複雑なポリマー構造と乱れに依存する.
  • 現在のメラニン合成方法は,ピグメント特性を正確に制御できない.

研究 の 目的:

  • 合成メラニンの調節可能な前駆体としてチロシンを含むトリペプチドの使用を調査する.
  • メラニンのような色素特性に対する 配列依存の制御を確立する.
  • これらのペプチド由来ピグメントの潜在的応用を探求する.

主な方法:

  • 定義されたアミノ酸配列を持つチロシンを含むトリペプチドを合成した.
  • これらのペプチド前駆体による酸化ポリメリゼーション.
  • 分光,顕微鏡,電気化学技術を用いて結果のポリマー色素を特徴づけた.

主要な成果:

  • 紫外線吸収,色付け,形質など,配列に依存した色素特性に対する制御を達成した.
  • 調節可能なフリーラジカルスキャビングと 電気化学的活性を示した.
  • ペプチド配列と結果のポリマーの物理的,化学的特性との相関が観察されました.

結論:

  • タイロシンを含むトリペプチドは,メラニンのような色素の有効で調節可能な前駆体として機能する.
  • ペプチド配列は pigmentの性質を設計する強力な戦略です
  • これらのペプチド由来の色素は,合成の容易さとスケーラビリティにより,化粧品や生物医学における短期的な応用が期待されています.