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Updated: Feb 28, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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キラル・イリジウム複合体によって触媒化されたエナンチオとダイアステロセレクティブのスパイロケタリゼーション

James Y Hamilton1, Simon L Rössler1, Erick M Carreira1

  • 1Eidgenössische Technische Hochschule Zürich , Vladimir-Prelog-Weg 3, HCI H335, 8093 Zürich, Switzerland.

Journal of the American Chemical Society
|June 10, 2017
PubMed
まとめ

イリジウム複合体の触媒は,アリル炭酸から複合スピロケタルの効率的な合成を可能にします. この方法は複数のステレオセンターを 1 ステップで設置し,多様な構造に広く適用できます.

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