看護師の予防接種は,生きている水ワクチンの接種です
Lancet (London, England)
|May 18, 1985
まとめ
この研究では,OKA-RIT varicella zoster virus (VZV) ワクチンが医療従事者にとって安全であることが判明しました. 抗体のレベルは時間の経過とともに低下しますが,細胞媒介免疫は持続し,水に対する保護を提供します.
科学分野:
- 免疫学 免疫学とは
- ワクチン学 ワクチン学
- 公衆衛生は公衆衛生である.
背景:
- 医療従事者は,水のゾスターウイルス (VZV) に曝露するリスクがあります.
- 血清陰性個体は,水を予防するためにワクチン接種を必要とします.
研究 の 目的:
- VZV-seronegativeの看護師において,生体弱化型水ワクチン (OKA-RIT株) の安全性と免疫性を評価する.
- ワクチン接種後の長期的な免疫を評価する.
主な方法:
- 34人のVZV陽性看護師がOKA-RIT株でワクチン接種を受けました.
- 参加者は最大36ヶ月間,血清学的および細胞媒介免疫評価で追跡されました.
- ワクチンの反応と水の発生をモニターした.
主要な成果:
- 主要な副作用は観察されなかった.
- 血清変換率は5ヶ月と1年で94%となり,3年後に64%に低下しました.
- 細胞媒介免疫 (リンパ球変容) は,ほとんどの参加者において検出可能であった.
- ワクチン接種を受けた看護師は,ワクチン接種を受けていない対照群と比較して,疹の発症率が低かった.
結論:
- OKA-RIT VZVワクチンは,成人の医療従事者に対して安全で免疫性があります.
- 長期免疫評価には,抗体と細胞媒介免疫検査の両方が必要です.
- ワクチン接種は,VZVの感染を防ぐために,感受性の高い医療従事者に推奨されます.
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