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Updated: Feb 28, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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癌の薬剤耐性の一種として,希少な細胞の変異性と薬物誘発による再プログラム

Sydney M Shaffer1,2, Margaret C Dunagin1, Stefan R Torborg1,3

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Nature
|June 14, 2017
PubMed
まとめ

癌細胞は稀な転写変化によって薬剤耐性を自発的に発達させることができる. 抗生物質の治療は エピジェネティック再プログラムによって この抵抗をロックし 希少な細胞集団における 多段階のプロセスを強調します

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