転写因子T-betを発現する調節性T細胞の安定性と機能
Andrew G Levine1, Alejandra Mendoza1, Saskia Hemmers1
1Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Nature
|June 14, 2017
まとめ
T- ベット転写因子を発現する調節性T細胞は安定しており,Tヘルパー1の自己免疫抑制に不可欠です. これらのT- ベット+ 調節性T細胞は免疫耐性を維持するために不可欠です.
科学分野:
- 免疫学
- 細胞生物学
背景:
- 適応免疫は,T-ベットのような転写因子によって定義されるCD4 T細胞のエフェクターサブセット (Tヘルパー1,Tヘルパー2,Tヘルパー17) に分化することを含む.
- Foxp3によって指定された調節性T (Treg) 細胞は,抗炎症性ですが,機能的な可塑性を示唆するエフェクターT細胞転写因子を発現することができます.
研究 の 目的:
- マウスの調節性T細胞におけるT-ベットの発現の安定性と機能を調査する.
- トレグ細胞のT-ベット発現が安定した分化または可逆的な可塑性を示すかどうかを判断する.
主な方法:
- マウスのTレグ細胞におけるTベット発現の誘導 安定状態および感染中に
- 非許容条件下でのT-bet表現の安定性を評価する.
- 免疫応答と自己免疫に対するT-ベット+Tレグ細胞喪失またはT-ベット発現操作の機能的影響を評価する.
主要な成果:
- Tレグ細胞のTベット発現は,一度誘導されると,許容しない条件下でも非常に安定します.
- Tベットの発現だけでなく,Tベットの発現するTレグ細胞の喪失または除去は,重度のTヘルパー1の自己免疫につながった.
- 残ったT- ベット+Tレグ細胞は,特異的にTヘルパー1とCD8T細胞の活性化を阻害し,エフェクターT細胞との局所と相関していた.
結論:
- T- ベット+ Tレグ細胞は,重要な免疫抑制機能を持っています.
- トレグ細胞集団内の機能的異質性は,免疫的耐性にとって不可欠である.
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