関連する実験動画

Updated: Feb 28, 2026

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Published on: June 27, 2018

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超コンパクトハンティングチンエクソン-1変異構造におけるβシートリッチコンフォーマーションの出現

Hongsuk Kang1, Francisco X Vázquez1, Leili Zhang1

  • 1Computational Biology Center, IBM Thomas J. Watson Research Center , Yorktown Heights, New York 10598, United States.

Journal of the American Chemical Society
|June 14, 2017
PubMed
まとめ

ハンチントン病 (HD) はハンチントンタンパク質 (Htt) のポリグルタミン (polyQ) と関連しています. 分子動力学シミュレーションでは,グルタミン側鎖の相互作用により,より長いポリQ経路が超コンパクトな構造を形成し,HDの病原性を説明しています.

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