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Updated: Feb 28, 2026

The Soft Agar Colony Formation Assay
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PTENはFBXL2に対抗して,IP3R3とCa2+媒介による腫瘍増殖を抑制するアポトーシスを促進する

Shafi Kuchay1,2,3, Carlotta Giorgi1,2,4, Daniele Simoneschi1,2

  • 1Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA.

Nature
|June 15, 2017
PubMed
まとめ

F- ボックスタンパク質 FBXL2は,ミトコンドリアのカルシウム過負荷とアポトーシスを制限して,分解のためにIP3R3をターゲットにします. この分解を阻害することは,PTENを抑制したがんの治療戦略です.

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