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Updated: Feb 28, 2026

Purification of Hsp104, a Protein Disaggregase
07:17

Purification of Hsp104, a Protein Disaggregase

Published on: September 30, 2011

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AAA+分解酵素Hsp104のラチェット型ポリペプチド転位機構

Stephanie N Gates1,2, Adam L Yokom1,2, JiaBei Lin3

  • 1Department of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Science (New York, N.Y.)
|June 17, 2017
PubMed
まとめ

Hsp104タンパク質分解剤は,毒性タンパク質を展開する回転メカニズムを使用します. Cryo-EM構造は,毛穴に保存されたチロシンが基板と相互作用し,転位を促し,プロテオスタシスを維持することを明らかにします.

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