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Updated: Feb 7, 2026

GPI Anchoring of Proteins in the ER Membrane
01:29

GPI Anchoring of Proteins in the ER Membrane

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バクテリアRNAポリメラーゼの抗菌ヌクレオシドアナログ阻害剤

Sonia I Maffioli1, Yu Zhang2, David Degen2

  • 1NAICONS Srl, 20139 Milan, Italy; Vicuron Pharmaceuticals, 21040 Gerenzano, Italy.

Cell
|June 17, 2017
PubMed
まとめ

科学者たちは,バクテリアのRNAポリメラーゼ (RNAP) を阻害する新しい化合物である偽ウリジミシン (PUM) を発見しました. この有望な薬剤候補は 薬剤耐性細菌に対する強力な活性を示し,マウスの感染を治します.

キーワード:
偽ウリジミシン (PUM)RNAポリメラーゼRNAポリメラーゼ阻害剤抗菌剤抗生物質抗菌剤耐性微生物抽出物のスクリーニングヌクレオシド・アナログ阻害剤トランスクリプショントランスクリプション阻害剤

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