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関連する概念動画

Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

11.1K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
11.1K
ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

5.0K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
5.0K
ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

6.6K
The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
6.6K
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

6.8K
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
6.8K
Anaphase A and B01:39

Anaphase A and B

5.6K
Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
5.6K
Indirect Motor Pathways01:22

Indirect Motor Pathways

3.7K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
3.7K

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関連する実験動画

Updated: Feb 28, 2026

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

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第3世代 光駆動型対称分子モーター

Jos C M Kistemaker1, Peter Štacko1, Diederik Roke1

  • 1Centre for Systems Chemistry, Stratingh Institute for Chemistry and Zernike Institute for Advanced Materials, Faculty of Mathematics and Natural Sciences, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Journal of the American Chemical Society
|June 20, 2017
PubMed
まとめ

過剰に混雑したアルケンを利用した 3世代分子モーターは 制御された表面運動を提供します ステリック・ハードランスと 擬似非対称性センターは 先進的なナノ機械の 回転速度と方向を 正確に調整します

さらに関連する動画

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation
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Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation

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Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
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Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

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関連する実験動画

Last Updated: Feb 28, 2026

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

12.1K
Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation
08:09

Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation

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Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
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科学分野:

  • 分子ナノテクノロジー
  • 有機化学
  • 超分子化学

背景:

  • シンメトリックな分子モーターには ステレオジェニックなセンターがなく 新しい機械システムを可能にします
  • 第三世代のモーターは 制御された表面運動を持つ 先進的なナノマシンの開発に不可欠です
  • 限界を理解することは 光駆動の回転分子機械を最適化するための鍵です

研究 の 目的:

  • 3世代目の光駆動分子モーターの 熱的・光化学的回転行動を調査する.
  • モーターの回転速度を制御するステリック障害の役割を解明する.
  • 代替チューニングによって回転運動の方向を正確に制御することを実証する.

主な方法:

  • 第3世代の分子モーターの合成と特徴付け
  • ローテーション行動の光化学と熱分析
  • 運動性能を予測し検証するための計算モデルです.

主要な成果:

  • コアユニットのステリック障害は,回転速度に大きな影響を与える.より小さなサイズは,より低い回転障壁につながります.
  • 擬似非対称な炭素の中心は,モーターの動きに単方向性を与えます.
  • ブリッジヘッド置換物のステリック効果の調節は,回転運動の方向を正確に制御します.
  • メチル置換剤を変化させ,設計された2つのモーターで逆回転を証明した.
  • 予測モデルに一致する高速モーターの両方のローターユニットに等しい回転速度を観測した.

結論:

  • ステリック効果は分子モーターの速度と方向を制御するのに不可欠です.
  • 第3世代の分子モーターは ナノマシンに 精密で調整可能な回転運動を提供します
  • これらの発見は,より高度な,機能的なダイナミックシステムの開発に道を開きます.