ヒトの腸内微生物群によるキセノバイオティクスの化学変換
Nitzan Koppel1, Vayu Maini Rekdal1, Emily P Balskus2,3
1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
Science (New York, N.Y.)
|June 24, 2017
まとめ
ヒトの腸内微生物群は 摂取した化合物を変化させ 薬の効能と毒性に影響します これらの微生物の異種生物の代謝経路を理解することは パーソナライズされた医学と毒理学にとって極めて重要です
科学分野:
- 微生物学
- 生物化学
- 薬理学について
背景:
- ヒトの腸内微生物群は,薬剤や食事中の化合物を含め,キセノバイオティクスの代謝に大きな影響を及ぼします.
- 微生物の異種生物の代謝経路は,しばしば宿主酵素経路と化学的に異なる.
- これらの変異を起こす特定の微生物,遺伝子,酵素は ほとんど特定されていません.
研究 の 目的:
- 腸内微生物の異種生物代謝を理解する重要性を強調する.
- 微生物の変異を特定の酵素とその生物学的効果と結びつけるという課題を強調する.
- 伝統的技術と新興技術の統合の可能性を強調し,この分野を前進させる
主な方法:
- 腸内微生物の異種生物代謝に関する現在の文献のレビュー.
- 微生物酵素とその機能の特定における課題の議論
- 多様な技術的アプローチを統合することを重視する.
主要な成果:
- 腸内微生物は 異種生物の多様性を変えて 変化した性質の代謝産物を作ります
- 腸内微生物の代謝化学は宿主酵素とは異なる.
- さまざまな研究技術を組み合わせることで進歩が進んでいます.
結論:
- 腸内微生物の異種生物代謝に関する包括的な分子理解は不可欠である.
- この知識は パーソナライズされた医療,栄養,毒理学を 進歩させるでしょう
- 薬の発見と開発過程も改善します
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