セレニウム欠乏症と,システィックフィブロシス症の成人のがん発症リスクの増加の可能性
Lancet (London, England)
|October 19, 1985
まとめ
性線維症 (CF) の若い成人は,しばしばセレニウムとビタミンEのレベルが低い. これらの欠陥は,特に高齢のCF患者において,がんのリスクを増やす可能性があります.
科学分野:
- バイオケミストリー バイオケミストリー
- 腫瘍学 腫瘍学
- 肺内科 肺内科 肺内科
背景:
- 囊性線維症 (Cystic Fibrosis,CF) は,複数の臓器に影響を与える遺伝疾患である.
- 栄養不足は,CFの患者でよく見られる.
- 酸化ストレスと炎症はCFの病原性に関与しています.
研究 の 目的:
- CFの若い成人の血清セレニウムとビタミンE濃度を調査する.
- これらの微量栄養素とCFにおけるがんリスクとの関連性を調べる.
主な方法:
- CFを患った20人の若年成人から血液サンプルを採取した.
- セレニウムとビタミンEの血清濃度が測定されました.
- コーホート内の癌発生率が記録されました.
主要な成果:
- ほとんどの参加者の血清セレニウム濃度が低いことが観察されました.
- 低血清ビタミンE濃度も一般的であった.
- CFの2人の参加者は,がんと診断されました.
結論:
- 低血流セレニウムレベルは,CF患者におけるがんのリスクの増加と関連している可能性があります.
- ビタミンEのレベルが低下すると,このリスクが悪化する可能性があります.
- CFの高齢者は,がんを発症するリスクの高いグループである可能性があります.
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