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Updated: Feb 27, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
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実用的な単体および二重電子性アミネート剤:炭素-窒素結合形成のための新しい,より持続可能なプラットフォーム

Padmanabha V Kattamuri1,2, Jun Yin1, Surached Siriwongsup1

  • 1Department of Chemistry, Rice University, BioScience Research Collaborative , Houston, Texas 77005, United States.

Journal of the American Chemical Society
|June 27, 2017
PubMed
まとめ

研究者達は 異なったアミンを合成するための 移行金属のない新しい方法を開発した. このアプローチでは,容易に入手できる核愛素と新しいアミネーション剤を用いて,C-N結合形成のスケーラブルでエコフレンドリーな代替手段を提供している.

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Amines to Amides: Acylation of Amines

Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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