アルケンの高エナンチオセレクティブコバルト触媒水酸化
Biao Cheng1, Peng Lu1, Heyi Zhang1
1Department of Chemistry, Zhejiang University , Hangzhou 310058, China.
Journal of the American Chemical Society
|June 28, 2017
まとめ
新しいコバルト触媒法により,アルケンからキラル二水素シランを効率的に合成する. このエナンチオセレクティブの水酸化は単純で,原子経済的で,様々な機能群を許容する.
科学分野:
- 有機金属化学
- 非対称な触媒
- 合成有機化学
背景:
- チラル・ジヒドロシランは有価な合成中間物質である.
- 合成のための効率的でエナチオセレクティブな触媒的方法の開発は依然として課題です.
- アルケンの水酸化は,シリコンを含む化合物への直接的な経路を提供します.
研究 の 目的:
- アルケンの新種のコバルト触媒によるエナチオセレクティブ水溶解を開発する.
- キラルジヒドロシランの合成のために高度なマルコヴニコフ型選択性を達成する.
- 簡単に入手可能な材料を使って,操作的にシンプルで原子経済的なプロトコルを作成します.
主な方法:
- コバルト触媒による水酸化反応
- アルケーン (アリルとアリファティック) とシリコンの源を使用した.
- 反応条件を最適化して,エナンチオセレクティブと産出量を改善する.
主要な成果:
- キラルジヒドロシランの高度なマルコヴニコフ型およびエナチオセレクティブ合成を達成した.
- 幅広いアルケンのための優れた機能的グループ耐性を示した.
- プロトコルは,操作的にはシンプルで,原子経済的で,グラムスケールまでスケーラブルで,高回転数 (TON) と高回転頻度 (TOF) がそれぞれ860と1800まであります.
結論:
- コバルト触媒によるアルケンの実用的で効率的なエナチオセレクティブ水酸化が開発された.
- この方法は,高い選択性と機能群耐性を持つ有価なキラルジヒドロシランへのアクセスを提供します.
- このプロトコルは,シリコンベースの化合物の非対称な触媒の重要な進歩を表しています.
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