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Updated: Feb 27, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
11:53

Substrate Generation for Endonucleases of CRISPR/Cas Systems

Published on: September 8, 2012

28.1K

型I CRISPR-Casシステムにおける指向Rループ形成と基板移転メカニズムの構造基盤

Yibei Xiao1, Min Luo2, Robert P Hayes1

  • 1Department of Molecular Biology and Genetics, Cornell University, 253 Biotechnology Building, Ithaca, NY 14853, USA.

Cell
|July 1, 2017
PubMed
まとめ

タイプIのCRISPRシステムは カスケードを使ってDNAを探し カスケードを使ってDNAを分解します 新しい冷凍電子顕微鏡構造は Cascade が DNA を解き放ち,Cas3 を採用し,標的の分解を開始する方法を明らかにしています.

キーワード:
CRISPRについてカス3カスケードPAM についてRループcrRNA についてヘリコース核酵素プロトスペーススパッサー

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