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Updated: Feb 27, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
09:16

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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転写因子RUNX1は,血小板PCTP (フォスファディチルコリン伝達タンパク質) を調節する.心血管疾患への影響:RUNX1変異の差異的効果

Guangfen Mao1, Natthapol Songdej1, Deepak Voora1

  • 1From Sol Sherry Thrombosis Research Center (G.M., N.S., F.E.D.C.-C., L.E.G., A.K.R.), Hematology Section, Department of Medicine (N.S., A.K.R.), and Department of Anatomy and Cell Biology (L.E.G.), Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and Duke Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC (D.V., R.A.M.).

Circulation
|July 6, 2017
PubMed
まとめ

RUNX1は,ポスファディチルコリン伝達タンパク質 (PCTP) の遺伝子発現を直接調節する. 心血管疾患の患者におけるPCTP濃度の上昇は,死亡または心筋梗塞のリスクの増加と相関しています.

キーワード:
ヒトのRUNX1タンパク質血小板心血管疾患フォスフォリピド転送タンパク質

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