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Updated: Feb 27, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
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SAMDI質量スペクトロメトリーによるタンパク質相互作用ドメインのプロファイリング

Patrick T O'Kane1, Milan Mrksich1

  • 1Department of Chemistry, Department of Biomedical Engineering, and Department of Cell & Molecular Biology, Northwestern University , Evanston, Illinois 60208, United States.

Journal of the American Chemical Society
|July 11, 2017
PubMed
まとめ

新しい測定法である SAMDIによるタンパク質相互作用 (PI-SAMDI) は,酵素活性を測定することによってタンパク質-リガンド結合親和性をプロファイルします. この方法は,リガンドの親和性を正確にランク付けし,クロストークの相互作用を明らかにし,高通量分析に適しています.

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