鬱病の症状を媒介する特徴的な腹部状神経群
Daniel Knowland1, Varoth Lilascharoen2, Christopher Pham Pacia2
1Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA USA; Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA USA.
Cell
|July 11, 2017
まとめ
研究者らは,うつ病に寄与するパーバルブミン陽性 (PV) 神経細胞を用いて,腹白皮質 (VP) の2つの異なる脳回路を特定しました. 抗うつ薬の治療はストレスによる変化を正常化し,症状特有のうつ病治療の可能性を示唆しています.
科学分野:
- 神経科学
- 精神科
- 分子生物学
背景:
- 重度のうつ病 (MDD) は様々な症状を呈し,効果的な治療を困難にします.
- 特定のうつ病の症状には 脳の異なる回路が 根底にあるかもしれませんが その役割や ストレスへの適応は 明らかになっていません
研究 の 目的:
- 腹部パリドーム (VP) の離散型パルバルブミン陽性 (PV) ニューロン回路とそのうつ病のような行動への貢献を調べる.
- この回路が社会的ストレスに 適応し 抗うつ薬の治療に 反応する方法を理解するためです
主な方法:
- 横のヘブンヌラまたは腹部のテグメンタル領域に投影するVPニューロンの電気生理学的記録.
- 社会的敗北のストレスに伴う行動適応の評価
- 神経活動と行動に対する抗うつ薬の治療効果の評価
主要な成果:
- 2つの異なるVPPニューロン回路が特定され,横側ヘブンヌラと腹部テグメンタル領域に投射された.
- これらの回路は,社会的敗北のストレスに対する 異なる電気生理学的適応を示した.
- 抗うつ薬は ストレスによる適応を 正常化させました
- それぞれの回路の選択的な操作は 社会的撤退や行動的絶望を媒介しましたが 両方ではありません
結論:
- 離散的なVP PVニューロン回路は,マウスの分離した,しかし関連した,うつ病のような現象型を基礎にすることができます.
- この発見は 症状特有のうつ病の治療法の開発に 潜在的な基盤を提供している.
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