関連する実験動画

Updated: Aug 12, 2026

Novel Apparatus and Method for Drug Reinforcement
07:32

Novel Apparatus and Method for Drug Reinforcement

Published on: August 20, 2010

流行のフリーベースコカイン乱用. バハマ諸島のケーススタディ

J F Jekel, D F Allen, H Podlewski

    Lancet (London, England)
    |March 1, 1986
    PubMed
    まとめ

    バハマのコカイン乱用入院者の急増は,コカイン塩化水素から,高度に中毒性の高いコカインフリーベースへの移行に関連していた. この変化は重大な公衆衛生危機を引き起こし,主にフリーベース・コカインによる全国的な伝染病が初めて報告されました.

    さらに関連する動画

    Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice10:28

    Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

    Published on: February 18, 2016

    A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder07:51

    A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

    Published on: June 18, 2018

    関連する概念動画

    Drug Dependence01:17

    Drug Dependence

    Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
    Drug Abuse and Addiction: Pharmacological Phenomena01:15

    Drug Abuse and Addiction: Pharmacological Phenomena

    Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
    CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

    CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

    CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
    Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

    Drug Accumulation During Multiple Dosing: Repetitive IV Injections

    Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
    Substance Use Disorders Affecting Sleep01:24

    Substance Use Disorders Affecting Sleep

    Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
    Understanding the concepts of physical dependence,...
    Stimulants01:29

    Stimulants

    Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
    Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...