収縮:INK4/ARFロクスの抑制によるCdc6の腫瘍性活性
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PubMedで要約を見る
まとめ
この要約は機械生成です。この研究は,以前に発表された論文 DOI を訂正しています. 修正は科学的研究の正確な引用と検索を保証し,科学的記録の完全性を維持します.
科学分野
- 科学出版
- 図書館情報
- 学術的なコミュニケーション
背景
- 正確な引用は 科学的な誠実さにとって極めて重要です
- デジタルオブジェクト識別子 (DOI) は,研究記事への信頼できるアクセスを保証します.
- DOIの誤りは,研究発見と帰属を妨げます.
研究 の 目的
- 掲載された記事の誤ったデジタルオブジェクト識別子 (DOI) を修正します.
- 科学的研究の正確な参照と検索を保証する.
- 学術的なコミュニケーションシステムの 整合性を維持するためです
主な方法
- 誤ったDOIの識別
- 発行者の記録を通して正しいDOIの検証.
- 科学コミュニティに修正通知を発行する.
主要な成果
- 誤ったDOIが特定され,修正されました.
- 正確なDOIが記事に関連付けられています.
- この訂正は,適切な引用とアクセスを容易にする.
結論
- DOIを含む正確なメタデータは,効果的な科学的な普及のために不可欠です.
- 校正メカニズムは科学文献の信頼性を維持するために不可欠です.
- DOIの正確性を確保することで,研究の再現性と追跡性をサポートします.
関連する概念動画
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...