関連する実験動画

Updated: Feb 26, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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Using the E1A Minigene Tool to Study mRNA Splicing Changes

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多価性 hnRNP アセンブリの哺乳類における規制拡大

Serge Gueroussov1, Robert J Weatheritt2, Dave O'Hanlon3

  • 1Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

Cell
|July 15, 2017
PubMed
まとめ

哺乳類の進化は,RNA結合タンパク質の本質的に乱れた領域 (IDRs) の代替スプライシング (AS) の影響を示しています. このASはタンパク質アセンブリの形成を制御し,遺伝子スプライシングを制御し,細胞の調節能力を拡張します.

キーワード:
代替スプライシング進化についてhnRNP についてマルチバレンツ・アセンブリフェーズ分離タンパク質障害

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