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関連する概念動画

The Replisome03:01

The Replisome

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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
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ロタキサンベースの分子機械による配列特異β-ペプチド合成

Guillaume De Bo1, Malcolm A Y Gall1, Matthew O Kitching1

  • 1School of Chemistry, University of Manchester , Oxford Road, Manchester, M13 9PL, United Kingdom.

Journal of the American Chemical Society
|July 21, 2017
PubMed
まとめ

この研究は,非タンパク質性アミノ酸を用いたβ-ホモ (β3) ペプチドを合成するための人工分子装置を導入する. この機械は,自然または人工的な手段だけで生成できない新しいペプチドを生成し,ネイティブの化学結合によってうまく動作します.

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科学分野:

  • 分子機械
  • 合成化学
  • バイオテクノロジー

背景:

  • リボソームは通常,タンパク質原性アミノ酸を用いてペプチドを合成する.
  • β3アミノ酸などの非タンパク質性アミノ酸は,特に連続的にリボソーム合成に挑戦しています.
  • 人工分子の機械は ペプチド合成のための新しい経路を提供します

研究 の 目的:

  • ロタキサン基の人工分子装置の 合成と動作を報告する
  • β-ホモ (β3) ペプチドのシーケンス固有の合成を実証する.
  • 人工機械の能力を探求する 挑戦的な結合移行状態を扱う.

主な方法:

  • ロタキサン基の人工分子装置の合成
  • ペプチド合成のために非タンパク質性β3アミノ酸を使用する.
  • ペプチド結合形成のためにネイティブ・ケミカル・リガーション (NCL) を使用する.
  • ペプチダゼによる触媒領域の除去を証明する.

主要な成果:

  • 人工分子装置の 合成と動作が成功しました
  • 配列特異のβホモ (β3) ペプチドの合成
  • 15か国と19か国の移行国における成功の証明
  • 人工と生物学的機械の組み合わせによるユニークなペプチド製品の生成.

結論:

  • 人工分子機械は,β-ホモ (β3) ペプチドのシーケンス固有の合成を行うことができます.
  • この人工機械による情報翻訳と互換性があります.
  • 人工機械と生物機械を統合することで 単独で達成できないペプチドが作れます