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Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
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フルクトーゼ-1,6-ビスホスファートとアルドラーゼは,AMPKによるグルコース検知を媒介する

Chen-Song Zhang1, Simon A Hawley2, Yue Zong1

  • 1State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian 361102, China.

Nature
|July 21, 2017
PubMed
まとめ

アルドラーゼは,AMP/ADPとは独立して,AMP活性化タンパク質キナーゼ (AMPK) を活性化するために,グルコースレベルを感知する. このメカニズムは,グルコース欠乏時にAMPKの活性化を調節するアルドラーゼにフルークトーゼ-1, 6 ビスホスファート (FBP) の結合を伴う.

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