エピジェネティックな可塑性と癌の特徴
William A Flavahan1, Elizabeth Gaskell1, Bradley E Bernstein2
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, and Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Science (New York, N.Y.)
|July 22, 2017
まとめ
染色体構造の表遺伝子異常は 遺伝子発現を変化させることで 癌を引き起こす可能性があります これらの変化は 保護性遺伝子を阻害したり 有害な遺伝子を促進したりして 腫瘍の発生を促す可能性があります
科学分野:
- 分子生物学
- 遺伝学
- 癌 生物学
背景:
- エピジェネティックメカニズムは遺伝子発現と細胞状態を制御する.
- 異常なエピジェネティック・ランドスケープは,がんを含む疾患の病原化に寄与する.
- 過剰な制限と過剰な許容性のクロマチンの状態には有害な効果があります.
研究 の 目的:
- 癌の発生と進化における表遺伝子異常の役割を検討する.
- 癌の特徴に エピジェネティックの変化が 寄与するかを議論します
主な方法:
- 癌における表遺伝的メカニズムに関する文献レビュー.
- クロマチンの状態が遺伝子発現と細胞運命をどのように影響するかを分析する.
- エピジェネティック異常と癌の特徴の関連性の検討
主要な成果:
- エピジェネティックの変化は,腫瘍抑制剤を抑制する制限状態や,腫瘍遺伝子の活性化を可能にする許容状態につながる可能性があります.
- これらのエピジェネティックの変化は 有利な変異を持つ癌細胞の選択を促すことができます
- エピジェネティック異常は 癌の典型的な特徴と関係しています
結論:
- エピジェネティック・ディスレギュレーションは 癌の発生と進行の重要な要因です
- エピジェネティックメカニズムをターゲットにすることで 癌治療の潜在的治療戦略が生まれます
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