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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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自発的および酵素的水解におけるグリコシルカチオン対アリルカチオン

Phillip M Danby1, Stephen G Withers1

  • 1Department of Chemistry, University of British Columbia , 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.

Journal of the American Chemical Society
|July 25, 2017
PubMed
まとめ

酵素によるプレニルとグリコシル移転反応は 驚くべき類似性を共有しています 研究者らは,グリコシド模倣剤として作用するバリエニルエーテルが,類似した動力学と移行状態で水解され,共通の酵素メカニズムが示唆されていることを発見した.

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