ラディカル・リレー・チャペロンによるアルコールの誘導βC-Hアミネーション
Ethan A Wappes1, Kohki M Nakafuku1, David A Nagib1
1Department of Chemistry and Biochemistry, The Ohio State University , Columbus, Ohio 43210, United States.
Journal of the American Chemical Society
|July 26, 2017
まとめ
新しいラディカル・リレー・チャペロンは,ベータ・カーボンにアンモニアを組み込み,アルコールの直接のβ-C-Hアミネーションを可能にします. この方法は,価値あるベータアミノアルコール類に効率的にアクセスできます.
科学分野:
- 有機化学
- 合成方法論
背景:
- アルコールの直接的なC−H機能化は,有機合成における重要な課題である.
- アルコールを選択的にアミネーションする方法を開発することは,有価な窒素を含む化合物にアクセスするために不可欠です.
研究 の 目的:
- アルコールの直接のβ-C-Hアミネーションのための新しいラジカル媒介戦略を開発する.
- 指示されたC-H機能化とアンモニアの組み込みのために,ラジカル・リレー・チャペロンを使用する.
主な方法:
- 選択的なC-H機能化のための 痕跡のないディレクターとして
- 1,5-水素原子移転 (HAT) を利用して指向された機能化.
- アルコールをイミダートに in situ 変換し,C-H アミネーションと水解が続く.
主要な成果:
- アルコールによるベータC-Hアミネーションの成功開発
- ベータ炭素位置での選択的C-H機能化の実証.
- ベータアミノアルコール類の効率的な合成 簡素化されたプロトコルで
結論:
- 開発された戦略はベータアミノアルコールの合成のための新しい経路を提供します.
- ダイレクトされたC-H機能化のために,ラジカル・リレー・シャペロンは効果的に使用できます.
- この方法では,アルコールのβ炭素にアンモニアを組み込むことができます.
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