妊娠中の血清リラクシン

A H MacLennan, R Nicolson, R C Green

Lancet (London, England)

|August 2, 1986

まとめ

血清リラクシン濃度は,妊娠後期には減少するが,出産中に上昇する. 低リラクシン値は早産のリスクを示し,高レベルは双子の妊娠で見られ,リラクシンが示唆される.

科学分野:

生殖内分泌学生殖内分泌学
妊産婦・胎児医学について
妊娠のホルモンによる調節

背景:

血清リラクシン (Serum relaxin) は,妊娠中の重要なホルモンである.
出産の始まりと進行におけるその正確な役割については,さらなる解明が必要である.

研究の目的:

妊娠の異なる段階における血清リラクシン免疫活性を調べる.
リラクシンレベルと自発的出産,早産,双子の妊娠を相関させるため.

主な方法:

302例の正常な単発妊娠を横断的に研究した.
血清リラクシン濃度を測定するために使用される放射性免疫測定法.
リラクシン濃度の比較妊娠初期,中期,第3四半期,出産中,出産後.

主要な成果:

妊娠初期/中期に比べると,第3 trimesterのリラクシン濃度は低かった.
spontaneous labor 発症した女性では,妊娠中にレラクシンが著しく低下する.
労働中に観察された最も高いリラクシンレベルは,産後減少しています.
シングル妊娠と比較して双子の妊娠における第3期リラクシン濃度の上昇.
早期出産の患者で,低下し,低いリラクシン濃度が観察されました.

結論:

血清リラクシンは,子宮内静止状態を維持する役割を果たす可能性があります.
リラキシンは子宮の成長と子宮頸部の成熟を促進します.
リラクシンレベルは,潜在的に早産リスクを予測し,複数の妊娠で異なる可能性があります.

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