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Updated: Jun 14, 2026

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.8K

長期にわたるMek1/2抑制は,胚性幹細胞の発達可能性を損なう

Jiho Choi1,2,3,4, Aaron J Huebner1,2,3,4, Kendell Clement3,4,5

  • 1Massachusetts General Hospital Department of Molecular Biology, Boston, Massachusetts 02114, USA.

Nature
|July 27, 2017
PubMed
まとめ

マウスの胚性幹細胞 (ES細胞) を2i/Lの媒介で長時間培養すると,不可逆的な表遺伝子変化が起こり,発育の可能性が低下する. Mek1/ 2抑制をSrc抑制に置き換えると,ES細胞の完全性と機能が保たれる.

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An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C11:53

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

Published on: June 1, 2018

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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

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