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Updated: Feb 25, 2026

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
11:57

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Published on: June 24, 2025

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アルツハイマー病を引き起こす変異は,γ-セクレタゼ-Aβn相互作用を不安定化することによってAβ長さにシフトする

Maria Szaruga1, Bogdan Munteanu2, Sam Lismont1

  • 1KU Leuven-VIB Center for Brain & Disease Research, VIB, 3000 Leuven, Belgium; Department of Neurosciences, Leuven Institute for Neuroscience and Disease, KU Leuven, 3000 Leuven, Belgium.

Cell
|July 29, 2017
PubMed
まとめ

アルツハイマー病の突然変異は 酵素処理を不安定化し より長いアミロイドベータペプチドを生成します これらの相互作用を安定させることで アルツハイマー病の進行を防ぐことができます.

キーワード:
アルツハイマー病アミロイドβアミロイド前駆体タンパク質酵素の熱活性プレシニリンタンパク質の熱可変性γ-セクレターゼ

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