関連する実験動画

Updated: Feb 25, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

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Gタンパク質結合受容体によるアレスティンの徴用のためのリン酸化コードの識別

X Edward Zhou1, Yuanzheng He2, Parker W de Waal2

  • 1VARI-SIMM Center, Center for Structure and Function of Drug Targets, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Cell
|July 29, 2017
PubMed
まとめ

研究者らは,リン酸化Gタンパク質結合受容体 (GPCRs) がアストリンと結合する方法を発見した. この発見は,GPCRによるアステリン徴募を阻止し,細胞シグナル伝達に影響を与える一般的なメカニズムを明らかにしています.

キーワード:
GPCR についてグルジアアレストイン偏ったシグナル薬物の発見膜タンパク質リン酸化コードロドプシン

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