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Updated: Feb 25, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

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Published on: March 15, 2016

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5 種 の 血管 疾患 と 関連 し て いる 遺伝子 変異 は,エンドテリン-1 遺伝子 発現 の 遠隔 調節 器 で ある

Rajat M Gupta1, Joseph Hadaya2, Aditi Trehan2

  • 1Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Cell
|July 29, 2017
PubMed
まとめ

PHACTR1遺伝子 (rs9349379) に近い一般的な遺伝的変異は,大動脈におけるエンドセリン1 (EDN1) 発現を調節することによって5つの血管疾患のリスクに影響を与えます. この発見は,血管疾患の病原性における遠隔の調節メカニズムを強調しています.

キーワード:
SNP について心血管疾患冠動脈疾患内皮細胞エンドセリン-1エピゲノミクス遺伝子増強剤全ゲノム関連研究高血圧片頭痛障害

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