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Updated: Feb 25, 2026

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation
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S100タンパク質のカルシウム媒介制御:アギテーター/シグナルブロックメカニズムによるアロステリック通信

Yiming Xiao1, Gary S Shaw1, Lars Konermann1

  • 1Department of Chemistry, The University of Western Ontario , London, Ontario N6A 5B7, Canada.

Journal of the American Chemical Society
|August 1, 2017
PubMed
まとめ

カルシウムイオンはS100A11タンパク質の結合部位の閉塞を阻害し,新しいアロステリックメカニズムを明らかにします. ラビル塩のブリッジは信号伝播を開始し,カルシウム結合を阻害し,従来のアロステリック経路モデルに挑戦します.

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