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Updated: Feb 25, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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ソニック・ヘッジホッグ/パッチ相互作用のマクロサイクルペプチド阻害剤の設計と進化

Andrew E Owens1, Ivan de Paola1, William A Hansen2

  • 1Department of Chemistry, University of Rochester , 120 Trustee Road, Rochester, New York 14627, United States.

Journal of the American Chemical Society
|August 1, 2017
PubMed
まとめ

研究者は,ソニック・ヘッジホッグ/パッチ相互作用を標的とした新しいマクロサイクルペプチド阻害剤 (HL2-m5) を開発した. この強力な阻害剤はヘッジホッグのシグナル伝達と Gli 制御された遺伝子転写を効果的に阻害し,がん研究のための新しいツールを提供します.

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