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DNA 損傷後のミトスの進行は,マイクロ核内のパターン認識を可能にします

Shane M Harding1, Joseph L Benci2,3,4, Jerome Irianto5,6,7

  • 1Department of Cancer Biology, Basser Center for BRCA, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

Nature
|August 1, 2017
PubMed
まとめ

遺伝子毒性がん治療は,細胞サイクルがミトーシスに進行し,微核の形成につながるため,炎症を遅らせます. このプロセスは,放射線と免疫チェックポイントの阻害と組み合わせた場合,アブスコパルの腫瘍反応に不可欠です.

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