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Other Disorders of Digestive System01:30

Other Disorders of Digestive System

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Glucose Transporters

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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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The immune...
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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セリアック病

Benjamin Lebwohl1, David S Sanders2, Peter H R Green3

  • 1Celiac Disease Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.

Lancet (London, England)
|August 2, 2017
PubMed
まとめ
この要約は機械生成です。

グルテンに敏感な人の免疫反応であるセリアック病の発生率は増加しています. グルテンフリーダイエットは効果的ですが 持続的な症状に対する新しい非食事療法が開発されています

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科学分野:

  • 胃腸内科
  • 免疫学
  • 遺伝学

背景:

  • セリアック病は 世界人口の約1%に及ぶ.
  • セリアック病の発生率は上昇しており 検出の改善というより 実際の増加を示唆しています
  • 遺伝的傾向のある個体において グルテン摂取によって引き起こされる 免疫媒介性疾患です

研究 の 目的:

  • セリアック病に関する現在の理解を再考する.
  • 診断基準と治療の課題について話し合うこと
  • 新興の非食事療法戦略を強調する

主な方法:

  • セリアック病に関する既存の文献のレビュー
  • 診断ガイドラインと治療結果の分析
  • 新しい治療法の進行中の臨床試験の概要

主要な成果:

  • 腹症は,重度の吸収不良から無症状の症例まで,様々な臨床的症状を呈する.
  • 診断は通常,十二指管縮症と高血圧の組織トランスグルタミンゼ抗体によるものです.
  • 欧州のガイドラインでは,特定の基準を満たす子供のバイオプシーなしの診断を許可しています.
  • グルテンフリーダイエットが主な治療法ですが,かなりの割合の患者が持続的な症状を経験します.

結論:

  • セリアック病は複雑で,発症率が増加し,症状も様々です.
  • グルテンフリーダイエットにこだわるのは 多くの患者にとって 難しいことです
  • 新しい非食事療法の開発は 耐性性セリアック病の管理に不可欠です