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High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States
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タンパク質の折りたたみ時の水素交換のモニタリング

T Reid Alderson1, Cyril Charlier1, Dennis A Torchia1

  • 1Laboratory of Chemical Physics, NIDDK, National Institutes of Health , Bethesda, Maryland 20892-0520, United States.

Journal of the American Chemical Society
|August 3, 2017
PubMed
まとめ

研究者たちは核磁共振 (NMR) を用いてタンパク質の折り畳み速度を観測する新しい方法を開発した. この技術は,最終的な水素結合が形成され,折り畳みダイナミクスに影響を与えるまで,タンパク質が溶けた球体の特性を保持することを明らかにします.

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