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Updated: Feb 25, 2026

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
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Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Published on: July 16, 2011

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UBE2Oは,末端の赤血球分化中にプロテオームを再構成する

Anthony T Nguyen1, Miguel A Prado1, Paul J Schmidt2

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|August 5, 2017
PubMed
まとめ

Ube2o遺伝子の変異は赤血球発達の過程で古いタンパク質の除去を妨げて貧血を引き起こす. UBE2Oはリボソームタンパク質を標的として分解し タンパク質を再構成します

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