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Updated: Feb 25, 2026

Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
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Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations

Published on: November 7, 2019

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UBE2Oは,多タンパク質複合体の孤児に対する品質管理因子です

Kota Yanagitani1, Szymon Juszkiewicz1, Ramanujan S Hegde2

  • 1Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.

Science (New York, N.Y.)
|August 5, 2017
PubMed
まとめ

ユビキチン結合酵素UBE2Oは,未組成のタンパク質サブユニット,すなわちオルファンを対象に分解します. この酵素は,タンパク質のホメオスタシスを維持し,欠陥のあるタンパク質複合体を排除することで,独立した品質管理因子として作用します.

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