臓器型血管系:記述的異質性から機能的病理学へ

Hellmut G Augustin^1,2, Gou Young Koh^3,4

¹Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), 69121 Heidelberg, Germany. augustin@angiogenese.de gykoh@kaist.ac.kr.

Science (New York, N.Y.)

|August 5, 2017

まとめ

組織の健康に不可欠な血管には独特の機能を持つ臓器特有の内皮細胞 (ECs) があります血管疾患の新たな治療目標となる.

科学分野:

血管生物学
内皮細胞生物学
器官型血管系

背景:

血管は循環と臓器の環境の間の重要なインターフェースとして機能します
血管のコントロールは組織ホメオスタシス,適応,発達,血静,炎症,代謝,癌,転移などの様々な生理学的プロセスに不可欠です.
臓器特有の内皮細胞 (ECs) は様々な血管機能を媒介し,その異質性は長い間認識されてきた.

研究の目的:

臓器型血管の分化と機能の理解における最近の進歩をレビューする.
ECの分化と血管床特有の機能を制御する分子機構を強調する.
血管機能障害に関連する疾患の治療のための器官型血管の理解の治療的可能性を強調する.

主な方法:

このレビューは,最近の研究成果をまとめています.
内皮細胞の分化メカニズムに焦点を当てている.
臓器特有の血管機能と異質性を調べる

主要な成果:

近年,臓器型血管の分化に関する理解が著しく進展しています.
異なった器官型機能的属性とECの分子制御メカニズムは,ますます解明されています.
血管機能不全は多くの慢性的で生命を脅かす病気に関連しています

結論:

臓器型血管のより深い分子理解は,新しい血管標的治療の開発の鍵です.
血管特有の機能をターゲットにすることで治癒不可能な病気の新たな治療法が提供されるかもしれません
血管医学の進歩には,ECの異質性と機能に関する研究が継続されることが不可欠です.

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