昆虫 の 脳 の 学習 記憶 センター の 完全な コネクトーム
Katharina Eichler1,2, Feng Li1, Ashok Litwin-Kumar3
1Howard Hughes Medical Institute Janelia Research Campus, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
Nature
|August 11, 2017
まとめ
研究者はドロソフィラキノコの体回路をマッピングし ケニオン細胞が 関連記憶の入力を統合する方法を明らかにしました この詳細な配線図は 学習と記憶のメカニズムの 理解を向上させます
科学分野:
- 神経科学
- 分子生物学
- 遺伝学
背景:
- 生存に不可欠な 関連学習は 複雑な神経回路に依存しています
- 関連記憶のための高次元の回路のシナプスレベルの組織を理解することは依然として課題です.
- ドロソフィラ菌は 昆虫の学習と記憶の 重要な部位です
研究 の 目的:
- ドロソフィラの幼虫体の シナプス配線図を再現する
- 関連記憶形成をサポートする回路アーキテクチャを明らかにする.
- この学習センター内の新しいつながりと 組織的原則を特定します
主な方法:
- 高解像度回路の再構築 シナプス解像度
- 綿密な解剖図で 菌の体内のニューロンの繋がり
- 差別化タスクの回路性能を評価するための計算モデリング.
主要な成果:
- ほとんどのケニオン細胞はランダムな入力組合せを受け,サブセットは単一の投影ニューロンからステレオタイプの入力を受けます.
- 相互のケニオン細胞-調節性ニューロン接続,調節性ニューロン-出力ニューロン接続,および広範な再発性ケニオン細胞接続を含む新しいカノニカル回路アーキテクチャが特定されました.
- 出力ニューロン間のステレオタイプ接続が観察され,学習された行動選択を潜在的に強化しました.
結論:
- 復元されたドロソフィラキノコの体回路は 結合記憶のシナプスレベルの設計図を提供します
- 特定された回路組織は,特定の入力パターンと新しい接続を含む,刺激差別を最適化します.
- この包括的な回路図は,学習と記憶のプロセスに関する将来の機能的調査を容易にするでしょう.
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